The Journal of the American Osteopathic Association, 2005/07, 105(7):330-331. doi: 10.7556/jaoa.2005.105.7.317, type of study: ,ct,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2005.105.7.317/html)

Keywords:

biomarkers [21]
clinical trial [674]
cranio-sacral osteopathy [231]
CV4 technique [14]
stress [116]

Abstract:

Background: The osteopathic tenets of structure and function being reciprocally interrelated have allowed us to hypothesize that osteopathic techniques may be used to decrease physiological imbalances due to emotional stress. The CV4 treatment technique has been described as having a multitude of therapeutic effects by stimulating the body’s inherent capacity to heal itself. These effects are postulated to occur through CSF redistribution and enhanced fluctuation, and mechanical effects on the autonomic centers located in and about the floor of the 4th ventricle. Hypothesis: Our student population is under psychological stress which can be reduced by a particular manipulative technique, CV-4, and the effect is demonstrated by a change in biomarkers of lipid peroxidation. Study design: Subjects were 33 volunteer OMS I and II. Subjects were studied in 3 different periods: 1. Non-stress period (baseline), 2. Stress period, and 3. Stress + intervention period. Intervention consisted on the subjects receiving either the CV4 treatment or a “sham” treatment on 8 consecutive days for 15 minutes per day. The response variables studied were: Vital sign: blood pressure and pulse and biomarkers of oxidation: lipid hydroperoxides and paraoxonase. Methods: Blood pressure and pulse were taken after resting for 5 minutes. Lipid hydroperoxides were measured by an end point iodometic technique at 365 nm. Paraoxonase was measured using a kinetic method at 37. Results: Pulse significantly increased during stress compared with the baseline and shows very little variation with CV4, same results were obtained with blood pressure. Lipid hypoperoxidation was increased in the stress conditions and significantly decreased with CV4. Paraoxonase activity decreases with stress and is not significantly modified by manipulation. Conclusion: Our data suggest that lipidperoxidation is sensitive to manipulation techniques and supports our hypothesis that CV4 may be a viable treatment in reducing psychological stress, which has many implications in our stress-filled western society.