Expert Review of Neurotherapeutics, 2022/04, 21(4):475-490. doi: 10.1080/14737175.2021.1900734, type of study: ,sr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

Free full text   (https://www.tandfonline.com/doi/abs/10.1080/14737175.2021.1900734?journalCode=iern20)

Keywords:

brain injuries [3]
traumatic [55]
cognitive behavioral therapy [7]
headache [164]
migraine disorders [7]
post-traumatic headache [4]
acupuncture [58]
biofeedback [17]
non-pharmacological interventions [1]
noninvasive brain stimulation [1]
post-concussion syndrome [4]
therapeutic exercise [2]
traumatic brain injury [21]
osteopathic manipulative treatment [3946]
OMT [3925]
systematic review [445]

Abstract:

INTRODUCTION: Post-traumatic headache (PTH), a common type of headache secondary to traumatic brain injury (TBI) or whiplash, carries a relevant burden on patients. PTH is still an undertreated condition because of limited pharmacological treatment options. Therefore, multimodal non-pharmacologic approaches, which account for comorbidities and biopsychosocial factors, are often used in PTH patients. AREAS COVERED: After providing a brief overview of PTH, a systematic review was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations on recently published (2015-2020) papers on non-pharmacological interventions for PTH. We also collected data on ongoing trials on this topic. Studies and results are reviewed and discussed. EXPERT OPINION: PTH is one of the most common complications of TBI and accounts for almost 4% of symptomatic headache disorders. The most common clinical presentations of PTH are migraine-like or tension type (TTH)-like headache, neck pain, cognitive complaints, and psychological/psychiatric symptoms. Growing evidence suggests that combined pharmacological and non-pharmacological interventions, encompassing noninvasive neuromodulation, physical therapy, cognitive-behavioral treatment, and education, may be the best approaches for PTH and related comorbidities. Acute/preemptive pharmacological treatments for PTH include drugs used for migraine and TTH. When PTH management is multidisciplinary, the patient benefits most.