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Effectiveness of Osteopathic Manipulative Treatment for Parkinson Disease

Journal: The Journal of the American Osteopathic Association Date: 2006/08, 106(8):Pages: 478. doi: Subito , type of study: pretest posttest design

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2006.106.8.471/html)

Keywords:

OMT [3752]
osteopathic manipulative treatment [3772]
pretest posttest design [217]

Abstract:

Hypotheses: We predict a significant difference in Unified Parkinson Disease Rating Scale (UPDRS) and Quality of Life Inventory (QLI) scores in favor of Parkinson Disease patients who receive OMT. Methods: We used a randomized, single blind, IRB approved, placebo-controlled parallel-group design. Twenty-seven PD patients were randomized with 14 placed in the treatment and 13 in the placebo (sham) group. All participants were given the same pretest measures of symptoms (UPDRS) and quality of life (QLI). Experimental participants received standardized OMT that included soft-tissue articulatory and muscle energy techniques. Sessions were 30 minutes 1 day per week for 6 weeks. The control group received a sham treatment consisting of standard OMT diagnostic techniques alone. All participants were re-administered the same pretest measures to assess effectiveness of OMT at the end of the study. Results: Mean pretest UPDRS scores were 27 (n=14, SD=9) for the treatment group and 36 (n=11, SD=17.8) for the control group. Mean posttest UPDRS scores for the treatment group were 24 (n=14, SD=8.6) and 32 (n=11, SD=18.4) for the control group. Pre-post UPDRS scores were not statistically significant by ANCOVA, F(2,24)=0.183, P=.834. Pre-post estimated marginal means for the UPDRS treatment group were 3 (n=14) and 4 (n=11) for the control group. Mean pretest QLI scores were 65 (n=14, SD=18) for the treatment group and 78 (n=11, SD=28) for the control group. Mean QLI posttest scores for the treatment group were 61 (n=14, SD=17) and 72 (n=11, SD=26) for the control group. QLI pre-post scores were not statistically significant by ANCOVA, F(2,24)=0.702, P=.506. Pre-post estimated marginal means (EMMs) for the QLI treatment group were 2 (n=14) and 7 (n=11) for the control group. Mean likert scores on the outgoing patient survey for the control group was 25 and 34 for the treatment group. Conclusions: EMMs reveal a trend towards improvement that is clinically significant and will inform treatment. Comments often revealed that participants found OMT most useful for increased mobility. This medical benefit derived from the OMT appeared to be retained and transferred to other ADLs. Future studies will examine this in greater detail using a larger sample size and greater demographic heterogeneity.


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