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The Immediate Effects of the Splenic Pump on Serum Level of C-reactive Protein in Normal Adults

Journal: The Journal of the American Osteopathic Association Date: 2006/08, 106(8):Pages: 474-475. doi: Subito , type of study: randomized controlled trial

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2006.106.8.471/html)

Keywords:

c-reactive protein [2]
randomized controlled trial [889]
splenic pump technique [3]

Abstract:

Hypothesis: Splenic pump technique will cause increased serum C-reactive protein (CRP) levels in normal adults when compared to sham treatment. Materials and Methods: In this IRB-approved unblinded study, normal adults (age 20–67, n=107) were randomized to receive the splenic pump technique (n=52) or light touch (n=55) for five minutes. The splenic pump consisted of 100 bimanual compressions and relaxations of tissues overlying the spleen. The serum level of CRP was measured at baseline, and at 30 and 60 minutes posttreatment. A non-parametric ANCOVA was used to test for statistical differences between the groups, and Friedman's tests were used for within-group comparisons. Results: The median (first quartile, third quartile) CRP levels in the treatment group were 0.428 mg/L (0.192, 1.956) at baseline, 0.512 mg/L (0.180, 1.943) at 30 minutes post-treatment, and 0.460 mg/L (0.182, 1.766) at 60 minutes post-treatment. The corresponding medians in the sham group were 0.440 mg/L (0.150, 2.040), 0.480 mg/L (0.142, 2.025), and 0.446 mg/L (0.140, 2.195). The changes within the treatment group and the sham group were not significant (P=0.30 and P=0.06, respectively). There was no statistically significant difference in the median serum levels of CRP between the treatment group and the sham group (P=0.46 and P=0.80 at 30 minutes and 60 minutes, respectively). Conclusions: The splenic pump technique does not appear to change the level of C-reactive protein at 30 or 60 minutes post-treatment compared to sham treatment.


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